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Primarily characterized by progressive degradation of articular cartilage, subchondral bone sclerosis, synovial inflammation, and weakened periarticular muscle strength (1), OA poses a substantial socioeconomic burden, with direct and indirect healthcare costs estimated at approximately 12.5% of the gross domestic product (GDP) in developed countries (2)

Acknowledgments This work was supported by NIH grant DK45334 Footnotes Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication

Energy landscape of protein folding [edit] The configuration space of a protein during folding can be visualized as an energy landscape

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& Cortijo, J